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An opioid agonist, codeine binds to the mu-opioid receptors in the brain and affects the central nervous system. It is metabolized in the liver and turns into morphine on the way to the brain. When it comes to agonist strength, morphine is 10 times more effective than mu-opioid receptors. Codeine or morphine binds to the mu-opioid receptor, causing the neuron to become hyperpolarized and release nociceptive neurotransmitters. By attaching to mu-opioid receptors, this medication has analgesic effects and raises a person's pain tolerance.

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